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3.Acting on ether bonds
1.Thioether hydrolases
adenosine
+ L-homocysteineH2O
L-homocysteine
S-adenosyl-L-homocysteine hydrolase (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydratation of S-adenosyl-L-homocysteine into adenosine and homocysteine. AdoHcyase is an ubiquitous enzyme which binds and requires NAD+ as a cofactor.
AdoHcyase is a highly conserved protein of about 430 to 470 amino acids.
As signature patterns, it has been selected two highly conserved regions. The first
pattern is located in the N-terminal section; the second is derived from a
glycine-rich region in the central part of AdoHcyase; a region thought to be
involved in NAD-binding.
Reference